Pain & CNS behavior CRO
Post-Operative Pain Models for Rats or Mice
The Brennan model of post-operative pain consist on the incision of the hindpaw. Spontaneous pain can be monitored by measuring how the animal distributes the weight on each hindpaws, with a disbalance onto the contralateral paw. IP injection of the mGluR1 antagonist A-841720 compound produced an analgesic effect as the animal distributes equally his weight on each paw. Mechanical allodynia and thermal hyperalgesia are also proposed as read-out.
Spared Nerve Injury Model
Chronic Constriction Injury Model
STZ-induced type I Diabetes Neuropathy Model
Carrageenan-induced pain
CFA-induced pain
Formalin-induced pain
Brennan model of incision pain
Phenotype Expertise S.A.R.L. capital social 1.500 euros. SIRET : 794 821 801 00014
